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A highly sensitive electrochemical biosensor based on AuNP-modified gold electrodes for selective determination of serum levels of crosslaps
- Source :
- 3 Biotech; October 2017, Vol. 7 Issue: 5 p1-10, 10p
- Publication Year :
- 2017
-
Abstract
- This article explains a step-wise protocol to develop an electrochemical sensor to quantify serum levels of C-telopeptide (CTX) crosslinks also known as crosslaps in a matter of minutes and with high level of accuracy. The technique needs only one-step (incubation) and can thus be used for point of care screening. Due to the excellent electrical properties of the as-prepared immunosensor, CTX levels were successfully measured from 1 to 1000 pg/mL. This is while the normal reference of the marker is 50–450 pg/mL, suggesting that the sensor can acceptably detect CTX. The results also showed a good correlation with ECLIA in measuring serum levels of CTX.
Details
- Language :
- English
- ISSN :
- 2190572X and 21905738
- Volume :
- 7
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- 3 Biotech
- Publication Type :
- Periodical
- Accession number :
- ejs43157208
- Full Text :
- https://doi.org/10.1007/s13205-017-0919-y