In Vitro and in Vivo Antitumor Properties of Tetrakis((trishydroxy- methyl)phosphine)gold(I) Chloride

A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride <BO>1</BO>, has been investigated for its antitumor properties. In vitro studies demonstrate that <BO>1</BO> is active against HCT-15, AGS, PC-3, and LNCaP tumor cells. Cell cycle analysis of the HCT-15 cells by flow cytometry revealed elongation of the G1 phase of the cell cycle leading to growth inhibition. Administration of <BO>1 </BO>to Balb/C mice inoculated with syngenic meth/A cells demonstrated statistically significant dose-dependent survival time.