Using Genetic and Epigenetic Markers to Improve Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia by Noninvasive Methods in Mexican Patients

Prostate cancer is the most common malignancy in Mexican men. To improve its detection and prevent needless biopsies, we investigated the convenience of a combined analysis of prostate-specific antigen, androgen-receptor gene CAG repeats, and glutathione-S-transferase P1 and Ras association domain family 1 isoform A gene promoter methylation as a noninvasive option. The data from 186 patients who had undergone prostate biopsy were studied. The combined analysis increased detection confidence and could avoid unnecessary prostate biopsies.