Cytotoxic Styrylpyrones from Goniothalamus amuyon<SUP>1</SUP>

Two new styrylpyrones, (6R,7R,8R)-8-methoxygoniodiol (<BO>1</BO>) and (6R,7R,8R)-8-chlorogoniodiol (<BO>2</BO>), together with seven known styrylpyrones and eight other known compounds, were isolated from the leaves and/or stems of Goniothalamus amuyon. The structures of <BO>1</BO> and <BO>2</BO> were elucidated by spectral data interpretation, and the absolute stereochemistry of styrylpyrones in the diol and triol series was confirmed by X-ray crystallographic analysis and CD spectral data. Compound <BO>2</BO> demonstrated significant selective cytotoxicity toward the HONE-1 cancer cell line.