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Acaulins A and B, Trimeric Macrodiolides from Acauliumsp. H-JQSF
- Source :
- Organic Letters; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Acaulin A (1) and its macrolactone ring-opened congener acaulin B (2) were characterized from the culture of Acauliumsp. H-JQSF (an isopod-associated fungus) as architecturally undescribed trimeric macrodiolides, with the former being antiosteoporotic at 0.4 μM in the prednisolone-induced osteoporotic zebrafish. Identification of acaudiolic acid (3) as the monomeric macrodiolide precursor facilitated the proposal of the acaulin biosynthetic pathway.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs45301504
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b00883