Back to Search
Start Over
Gold-Catalyzed Post-Ugi Ipso-Cyclization with Switchable Diastereoselectivity
- Source :
- The Journal of Organic Chemistry; July 2018, Vol. 83 Issue: 15 p8170-8182, 13p
- Publication Year :
- 2018
-
Abstract
- A gold-catalyzed post-Ugi ipso-cyclization for the diastereoselective synthesis of spirocyclic pyrrol-2-one-dienone system is described. Tuning the catalytic system, solvent, and temperature allowed selectively attaining two sets of diastereoisomers. The scope of the process has been evaluated, and a putative mechanistic model was proposed.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 83
- Issue :
- 15
- Database :
- Supplemental Index
- Journal :
- The Journal of Organic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs45946250
- Full Text :
- https://doi.org/10.1021/acs.joc.8b00953