Back to Search
Start Over
Hexadecylphosphocholine selectively upregulates expression of intracellular adhesion molecule-1 and class I major histocompatibility complex antigen in human monocytes
- Source :
- Journal of Experimental Therapeutics and Oncology; November 2002, Vol. 2 Issue: 6 p333-336, 4p
- Publication Year :
- 2002
-
Abstract
- U 937 cells are widely used as a model system to study human monocytes, since they express typical human monocyte markers and properties. Hexadecylphosphocholine (HPC) is the main representative of a class of synthetic phospholipids, the alkylphosphocholines (APCs), and is able to form stable multilamellar vesicles (MLVs = liposomes) to deliver HPC to monocytes/macrophages. Here we report the ability of both micellar and liposomal HPC (L-HPC) to interact with human monocytes and upregulate specific adhesion molecules. Whereas CD14 could neither be induced by HPC nor by L-HPC on U 937 cells, intracellular adhesion molecule-1 and class 1 major histocompatibility complex (MHC-1) antigen were upregulated by both HPC and L-HPC in a dose-dependent manner. These data support and complete previous studies on HPC-induced activation of U 937 cells and provide additional mechanistic information on the initial steps of HPC-mediated recruitment of macrophages and their antitumor activity.
Details
- Language :
- English
- ISSN :
- 13594117 and 1533869X
- Volume :
- 2
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Experimental Therapeutics and Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs4598532
- Full Text :
- https://doi.org/10.1046/j.1359-4117.2002.01048.x