Congophilic Fibrillary Glomerulonephritis: A Case Series

Authors :: Alexander, Mariam P.
Dasari, Surendra
Vrana, Julie A.
Riopel, Julie
Valeri, Anthony M.
Markowitz, Glen S.
Hever, Aviv
Bijol, Vanesa
Larsen, Christopher P.
Cornell, Lynn D.
Fidler, Mary E.
Said, Samar M.
Sethi, Sanjeev
Herrera Hernandez, Loren Paola
Grande, Joseph P.
Erickson, Stephen B.
Fervenza, Fernando C.
Leung, Nelson
Kurtin, Paul J.
Nasr, Samih H.
Source :: American Journal of Kidney Diseases; September 2018, Vol. 72 Issue: 3 p325-336, 12p
Publication Year :: 2018
Abstract: Congo Red positivity with birefringence under polarized light has traditionally permitted classification of organized glomerular deposits as from amyloid or nonamyloid diseases. The absence of congophilia has been used to differentiate fibrillary glomerulonephritis (GN) from amyloidosis. We describe a series of fibrillary GN cases in which the deposits are Congo Red–positive (congophilic fibrillary GN) and discuss the role of DNAJB9 in distinguishing congophilic fibrillary GN from amyloidosis.