Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

•Erectile dysfunction is one of the most common sexual disorders among man.•Main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is).•Consumers see herbal supplements as ‘healthier’ and safer than conventional drugs.•Adulteration of food supplements with PDE5Is and/or its analogues is very common.•Adulteration represents serious source of toxicity and public health concern.