THE EFFECT OF CLOMIPHENE ON ENDOCRINE FUNCTION IN NORMAL MEN

The effect of clomiphene on hormone excretion in four normal males has been investigated.In all subjects there was a marked rise in the urinary excretion of oestrone and oestradiol both during and after administration of the drug. The rise in oestrone excretion preceded and was more marked than the increase in oestriol output.All subjects showed an increase in total 17-oxosteroid excretion during and after clomiphene administration. This was associated with a rise in the output of dehydroepiandrosterone in 2 of the 4 men studied.The effect of clomiphene on steroid output occurred without any consistent change in the pattern of urinary gonadotrophin excretion.