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PPh3AuTFA Catalyzed in the Dearomatization of 2-Naphthols with Allenamides
- Source :
- Organic Letters; November 2018, Vol. 20 Issue: 23 p7380-7383, 4p
- Publication Year :
- 2018
-
Abstract
- A new catalytic methodology for the direct dearomatization of substituted 2-naphthols via intermolecular condensation with allenamides is presented. PPh3AuTFA (5 mol %) promotes the formal allylating dearomative protocol under mild conditions, large scope (24 examples), and high regioselectivity and stereoselectivity. The synergistic catalytic role played by the [PPh3Au]+(π-acid) and TFA–(Lewis base) is highlighted.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 20
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs47013188
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b03018