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Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle

Authors :
Franck, Agathe
Lainé, Jeanne
Moulay, Gilles
Lemerle, Eline
Trichet, Michaël
Gentil, Christel
Benkhelifa-Ziyyat, Sofia
Lacène, Emmanuelle
Bui, Mai Thao
Brochier, Guy
Guicheney, Pascale
Romero, Norma
Bitoun, Marc
Vassilopoulos, Stéphane
Source :
Molecular Biology of the Cell; March 2019, Vol. 30 Issue: 5 p579-590, 12p
Publication Year :
2019

Abstract

In muscle, clathrin plaques form microdomains that anchor a three-dimensional desmin intermediate filament web. Depletion of clathrin plaques, dynamin 2, and branched actin cause accumulation of desmin tangles in the cytoplasm, while centronuclear myopathy–causing dynamin 2 mutations lead to desmin disorganization in mice and humans.

Details

Language :
English
ISSN :
10591524 and 19394586
Volume :
30
Issue :
5
Database :
Supplemental Index
Journal :
Molecular Biology of the Cell
Publication Type :
Periodical
Accession number :
ejs47897998
Full Text :
https://doi.org/10.1091/mbc.E18-11-0718