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Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle
- Source :
- Molecular Biology of the Cell; March 2019, Vol. 30 Issue: 5 p579-590, 12p
- Publication Year :
- 2019
-
Abstract
- In muscle, clathrin plaques form microdomains that anchor a three-dimensional desmin intermediate filament web. Depletion of clathrin plaques, dynamin 2, and branched actin cause accumulation of desmin tangles in the cytoplasm, while centronuclear myopathy–causing dynamin 2 mutations lead to desmin disorganization in mice and humans.
Details
- Language :
- English
- ISSN :
- 10591524 and 19394586
- Volume :
- 30
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Molecular Biology of the Cell
- Publication Type :
- Periodical
- Accession number :
- ejs47897998
- Full Text :
- https://doi.org/10.1091/mbc.E18-11-0718