C677T Methylene-H4-Folate-Reductase Variant Decreases Binocular Accommodation

Authors :: Krumdieck, Carlos L.
Fernandez, Jose R.
Desmond, Renee A.
Kleinstein, Robert N.
Shipp, Melvin D.
Prince, Charles W.
Source :: Optometry and Vision Science; March 2008, Vol. 85 Issue: 3 p196-200, 5p
Publication Year :: 2008
Abstract: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). In this study we examined 100 apparently normal subjects of both sexes (average age 25.6 ± 4.25) for the genotypic presence of the T allele and its association with accommodative amplitude (AA).