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Antitumor Effects and Immunomodulating Activities of Phellinus linteusExtract in a CT-26 Cell-Injected Colon Cancer Mouse Model
- Source :
- Mycobiology; June 2009, Vol. 37 Issue: 2 p128-132, 5p
- Publication Year :
- 2009
-
Abstract
- The antitumor effects of Phellinus linteusextract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 μg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
Details
- Language :
- English
- ISSN :
- 12298093 and 20929323
- Volume :
- 37
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Mycobiology
- Publication Type :
- Periodical
- Accession number :
- ejs48442507
- Full Text :
- https://doi.org/10.4489/MYCO.2009.37.2.128