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Effect of Iron Chelation on Myocardial Infarct Size and Oxidative Stress in ST-Elevation–Myocardial Infarction
- Source :
- Circulation: Cardiovascular Interventions; April 2012, Vol. 5 Issue: 2 p270-278, 9p
- Publication Year :
- 2012
-
Abstract
- Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.
Details
- Language :
- English
- ISSN :
- 19417640 and 19417632
- Volume :
- 5
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Circulation: Cardiovascular Interventions
- Publication Type :
- Periodical
- Accession number :
- ejs48489021
- Full Text :
- https://doi.org/10.1161/CIRCINTERVENTIONS.111.966226