A Rare Variant at the KYNUGene Is Associated With Kynureninase Activity and Essential Hypertension in the Han Chinese Population

Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population.