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A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer
- Source :
- Journal of Immunotherapy; May 2017, Vol. 40 Issue: 4 p132-139, 8p
- Publication Year :
- 2017
-
Abstract
- Supplemental Digital Content is available in the text.We examined the immunologic effects of allogeneic hematopoietic stem cell transplantation (HSCT) in the treatment of pancreatic ductal adenocarcinoma, a deadly disease with a median survival of 24 months for resected tumors and a 5-year survival rate of 6%. After adjuvant chemotherapy, 2 patients with resected pancreatic ductal adenocarcinoma underwent HSCT with HLA-identical sibling donors. Comparable patients who underwent radical surgery, but did not have a donor, served as controls (n=6). Both patients developed humoral and cellular (ie, HLA-A*01:01-restricted) immune responses directed against 2 novel tumor-associated antigens (TAAs), INO80E and UCLH3 after HSCT. Both TAAs were highly expressed in the original tumor tissue suggesting that HSCT promoted a clinically relevant, long-lasting cellular immune response. In contrast to untreated controls, who succumbed to progressive disease, both patients are tumor-free 9 years after diagnosis. Radical surgery combined with HSCT may cure pancreatic adenocarcinoma and change the cellular immune repertoire capable of responding to clinically and biologically relevant TAAs.
Details
- Language :
- English
- ISSN :
- 15249557
- Volume :
- 40
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Immunotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs48615176
- Full Text :
- https://doi.org/10.1097/CJI.0000000000000164