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Asymmetric Syntheses of Both Enantiomers of Amphetamine Hydrochloride viaBakers’ Yeast Reduction of Phenylacetone

Authors :
Shi, Xiao-Xin
Yao, Jian-Zhong
Kang, Li
Shen, Chun-Li
Yi, Fei
Source :
Journal of Chemical Research; October 2004, Vol. 2004 Issue: 10 p681-683, 3p
Publication Year :
2004

Abstract

Both enantiomers of amphetamine hydrochloride were stereospecifically synthesised based on bakers’ yeast reduction of phenylacetone. A simple and efficient method for the chiral inversion of (S)-1-phenyl-2-propanol 3to (R)-1-phenyl-2-propanol 8has been discussed.

Details

Language :
English
ISSN :
17475198 and 20476507
Volume :
2004
Issue :
10
Database :
Supplemental Index
Journal :
Journal of Chemical Research
Publication Type :
Periodical
Accession number :
ejs48768115
Full Text :
https://doi.org/10.3184/0308234043431843