Reappraisal of a single-tissue compartment model for estimation of myocardial oxygen consumption by 11Cacetate PET

Myocardial washout kinetics of carbon-11 labelled acetate (11Cacetate) by positron emission tomography (PET) closely correlate with myocardial oxygen consumption (MVO2). Analysis of the tissue time activity curve by conventional monoexponential curve fitting, however, does not account for spillover effects and recirculating 11C activity. In theory, a compartment model considering variations of the arterial input function and metabolic 11C contamination, could improve consistency of MVO2estimations. The objective of the study was to investigate this hypothesis.