Relationship of regional cerebral blood flow and kinetic behaviour of O-(2-18F-fluoroethyl)-L-tyrosine uptake in cerebral gliomas

O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is an established tracer for brain tumour imaging. 18F-FET kinetics in gliomas appear to have potential for tumour grading, but the mechanisms remain unclear. The aim of this study was to explore the relationship between regional cerebral blood flow (rCBF) as measured by arterial spin labelling MRI and the kinetic behaviour of 18F-FET PET in cerebral gliomas.