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960 DEVELOPMENT OF THE NOVEL GENE SILENCER PYRROLE-IMIDAZOLE POLYAMIDES TARGETING TGF-1 FOR FIBROTIC DISEASES
- Source :
- Journal of Hypertension; September 2012, Vol. 30 Issue: Supplement 1 pe278-e278, 1p
- Publication Year :
- 2012
-
Abstract
- Pyrrole-imidazole (PI) polyamides are novel gene silencers that inhibit promoter activity by its strong binding on DNA to block binding of transcription factor. PI polyamides can be freely designed and synthesized to promoter of any genes that are transcriptionaly responsible for the cause of diseases. We have developed PI polyamides targeting TGF-1 for fibrotic deseases.
Details
- Language :
- English
- ISSN :
- 02636352 and 14735598
- Volume :
- 30
- Issue :
- Supplement 1
- Database :
- Supplemental Index
- Journal :
- Journal of Hypertension
- Publication Type :
- Periodical
- Accession number :
- ejs48861677
- Full Text :
- https://doi.org/10.1097/01.hjh.0000420879.53417.84