Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

Methylglyoxal, a metabolite of the glycolysis pathway, may play an important role in the development of diabetes and hypertension, but the exact mechanism has not been fully elucidated. The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague–Dawley rats.