The PlA1/A2polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension increased risk of ischemic stroke in high-risk patients

The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa PlA1/A2polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk factor for stroke in hypertensive patients.