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Natural Disruption of Group 2 Phospholipase A2Gene Protects Against Choline-deficient Ethionine-supplemented Diet-induced Acute Pancreatitis and Lung Injury

Authors :
Kihara, Yasuyuki
Yoshikawa, Hiroyuki
Honda, Hidekazu
Fukumitsu, Ken-ichirou
Yamaguchi, Taizou
Otsuki, Makoto
Source :
Pancreas; July 2005, Vol. 31 Issue: 1 p48-53, 6p
Publication Year :
2005

Abstract

Group 2 phospholipase A2 (PLA2) plays an important role in the pathogenesis of multiple organ failure associated with acute pancreatitis. C57 BL/6J mice are natural group 2 PLA2 knockout mice lacking group 2 PLA2 mRNA. To clarify the role of group 2 PLA2 in the exacerbation of acute pancreatitis, we studied the biologic and histologic alterations in choline-deficient and ethionine-supplemented (CDE) diet-induced pancreatitis in group 2 PLA2-deficient C57 BL/6J mice and compared them with those in wild-type mice.

Details

Language :
English
ISSN :
08853177 and 15364828
Volume :
31
Issue :
1
Database :
Supplemental Index
Journal :
Pancreas
Publication Type :
Periodical
Accession number :
ejs48926191
Full Text :
https://doi.org/10.1097/01.mpa.0000168223.43709.28