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Pharmacokinetics of Micafungin in Pediatric Patients With Invasive Candidiasis and Candidemia
- Source :
- The Pediatric Infectious Disease Journal; June 2012, Vol. 31 Issue: 6 p630-632, 3p
- Publication Year :
- 2012
-
Abstract
- Although micafungin pharmacokinetic values were comparable between younger (<5 years) and older children (≥5 years) with candidemia and invasive candidiasis, younger children had a lower peak plasma micafungin concentration, lower micafungin exposure and larger micafungin clearance. Half-life remained unchanged with repeated dosing. Metabolite plasma concentrations remained low in older children; however, metabolite M-5 concentrations were higher in younger children.
Details
- Language :
- English
- ISSN :
- 08913668 and 15320987
- Volume :
- 31
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- The Pediatric Infectious Disease Journal
- Publication Type :
- Periodical
- Accession number :
- ejs48947579
- Full Text :
- https://doi.org/10.1097/INF.0b013e31824ab9b0