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Parietal cortex activation predicts memory decline in apolipoprotein E-4 carriers
- Source :
- NeuroReport; November 2006, Vol. 17 Issue: 16 p1683-1686, 4p
- Publication Year :
- 2006
-
Abstract
- Apolipoprotein E-4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondemented apolipoprotein E-4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-4 carriers, and hence likely progression to Alzheimer's disease.
Details
- Language :
- English
- ISSN :
- 09594965 and 1473558X
- Volume :
- 17
- Issue :
- 16
- Database :
- Supplemental Index
- Journal :
- NeuroReport
- Publication Type :
- Periodical
- Accession number :
- ejs48973530
- Full Text :
- https://doi.org/10.1097/01.wnr.0000239954.60695.c6