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Linoleic acid derivative DCP-LA improves learning impairment in SAMP8
- Source :
- NeuroReport; January 2006, Vol. 17 Issue: 1 p105-108, 4p
- Publication Year :
- 2006
-
Abstract
- In the water-maze test, the linoleic acid derivative, 8-2-(2-pentyl-cyclopropylmethyl)-cyclopropyl-octanoic acid (DCP-LA) (1 mgkg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the open-field test to assess motor activity, it was confirmed that the DCP-LA effect is not due to increased motor activity. In the passive avoidance test to assess fear memory, DCP-LA had no effect on the latency of acquisition and retention for SAMP8. The results of the present study, thus, suggest that DCP-LA could improve age-related learning impairment by enhancing cognitive functions.
Details
- Language :
- English
- ISSN :
- 09594965 and 1473558X
- Volume :
- 17
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- NeuroReport
- Publication Type :
- Periodical
- Accession number :
- ejs48973724
- Full Text :
- https://doi.org/10.1097/01.wnr.0000194388.12408.0a