Prospective Randomized Trial Between Two Doses of Granulocyte Colony-Stimulating Factor After Ifosfamide, Carboplatin, and Etoposide in Children With Recurrent or Refractory Solid Tumors A Children's Cancer Group Report

Authors :: Cairo, Mitchell S.
Shen, Violet
Krailo, Mark D.
Bauer, Madeline
Miser, James S.
Sato, Judith K.
Blatt, Julie
Blazar, Bruce R.
Frierdich, Sharon
Liu-Mares, Wen
Reaman, Gregory H.
Source :: Journal of Pediatric Hematology / Oncology; January 2001, Vol. 23 Issue: 1 p30-38, 9p
Publication Year :: 2001
Abstract: The objectives of this study were 1) to compare the time to hematologic recovery (absolute neutrophil count ANC =1,000/mm3and platelet count =100,000/mm3) in a randomized prospective study of two doses of granulocyte colony-stimulating factor (G-CSF) (5.0 vs. 10.0 g/kg per day) after ifosfamide, carboplatin, and etoposide (ICE) chemotherapy; and 2) to determine the response rate (complete response CR partial response PR) of ICE in children with refractory or recurrent solid tumors.

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