Cognitive deficits and degeneration of interneurons in HIVmethamphetamine users

Authors :: Chana, G
Everall, I P.
Crews, L
Langford, D
Adame, A
Grant, I
Cherner, M
Lazzaretto, D
Heaton, R
Ellis, R
Masliah, E
Source :: Neurology (Ovid); October 2006, Vol. 67 Issue: 8 p1486-1489, 4p
Publication Year :: 2006
Abstract: The cellular basis for cognitive deficits in HIVpatients with and without a history of methamphetamine (METH) use is unclear. We found that HIVMETH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIVMETH users.