Progranulingenetic variability contributes to amyotrophic lateral sclerosisSYMBOLSYMBOL

Authors :: Sleegers, K
Brouwers, N
Maurer-Stroh, S
Es, M A. van
Damme, P Van
Vught, P W.J. van
van der Zee, J
Serneels, S
Pooter, T De
Van den Broeck, M
Cruts, M
Schymkowitz, J
Jonghe, P De
Rousseau, F
Berg, L H. van den
Robberecht, W
Broeckhoven, C Van
Source :: Neurology (Ovid); July 2008, Vol. 71 Issue: 4 p253-259, 7p
Publication Year :: 2008
Abstract: Null mutations in progranulin(PGRN) cause ubiquitin-positive frontotemporal dementia (FTD) linked to chromosome 17q21 (FTDU-17). Here we examined PGRNgenetic variability in amyotrophic lateral sclerosis (ALS), a neurodegenerative motor neuron disease that overlaps with FTD at a clinical, pathologic, and epidemiologic level.

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