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A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain
- Source :
- Neurology (Ovid); December 2002, Vol. 59 Issue: 11 p1694-1700, 7p
- Publication Year :
- 2002
-
Abstract
- Nerve injury results in increases in spinal glutamate, which opens the NMDA ionophore channel, causing an influx of calcium. A glycine-binding site must be occupied for the channel to open. GV196771 is a selective antagonist of the glycine-binding site of the NMDA ionophore.
Details
- Language :
- English
- ISSN :
- 00283878 and 1526632X
- Volume :
- 59
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Neurology (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs49028528