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Seronegativity for type 1 antineuronal nuclear antibodies 'antiHu' in subacute sensory neuronopathy patients without cancer
- Source :
- Neurology (Ovid); November 1993, Vol. 43 Issue: 11 p2209-2211, 3p
- Publication Year :
- 1993
-
Abstract
- We followed 21 patients with sensory neuronopathy without evidence of cancer for up to 23 years. All were seronegative for type 1 antineuronal nuclear antibodies (ANNA-1, also called “anti-Hu”). We additionally studied 67 seropositive patients with sensory neuronopathy or a related neurologic syndrome. Ninety-one percent of the seropositive patients had a small-cell lung carcinoma. One, with a normal chest x-ray, had been followed for 7 years for sensory neuronopathy of indeterminate cause before serologic testing for ANNA-1 led to the discovery of the tumor by CT. We conclude that ANNA-1 seropositivity in a patient with sensory neuronopathy is strong evidence for an underlying small-cell lung cancer.
Details
- Language :
- English
- ISSN :
- 00283878 and 1526632X
- Volume :
- 43
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Neurology (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs49043432