Back to Search
Start Over
Vigabatrin in drugresistant partial epilepsy
- Source :
- Neurology (Ovid); April 1991, Vol. 41 Issue: 4 p562-565, 4p
- Publication Year :
- 1991
-
Abstract
- We treated 75 patients with drug-resistant complex partial seizures and secondarily generalized seizures with vigabatrin as additional therapy for 6 months. Twenty-one patients either showed no benefit from vigabatrin treatment or had side effects. The remaining 54 patients entered into the long-term study. The median monthly seizure frequency decreased from 12.5 at baseline to 3.3 at the 3-month visit, and was 3.9 after 5 years of therapy in 28 patients who continued using the drug after the 5-year period. During 5 years of therapy with vigabatrin, 26 patients have withdrawn from the study because of various reasons: loss of efficacy (14), suspected side effects (5), noncompliance (3), administrative reasons (2), pregnancy (1), and epilepsy surgery (1). In all, 19 patients had a greater than 50 seizure frequency reduction at 5 years, representing 35 of the 54 patients who entered the long-term study, or 25 of the 75 patients who were initially recruited into the efficacy study.
Details
- Language :
- English
- ISSN :
- 00283878 and 1526632X
- Volume :
- 41
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Neurology (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs49045237