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A Novel Pharmacologic Inhibitor of the NLRP3Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse
- Source :
- Journal of Cardiovascular Pharmacology; April 2014, Vol. 63 Issue: 4 p316-322, 7p
- Publication Year :
- 2014
-
Abstract
- The formation of the NLRP3inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim of this study was to measure the effects on the NLRP3inflammasome of 16673-34-0, an intermediate substrate free of the cyclohexylurea moiety, involved in insulin release.
Details
- Language :
- English
- ISSN :
- 01602446 and 15334023
- Volume :
- 63
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Cardiovascular Pharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs49051510
- Full Text :
- https://doi.org/10.1097/FJC.0000000000000053