Back to Search
Start Over
Effects of βAdrenergic Blockade on the Glomerular and Tubular Response to Acute Renal Denervation
Effects of βAdrenergic Blockade on the Glomerular and Tubular Response to Acute Renal Denervation
- Source :
- Journal of Cardiovascular Pharmacology; March 1991, Vol. 17 Issue: 3 p397-402, 6p
- Publication Year :
- 1991
-
Abstract
- Using micropuncture techniques in euvolemic adult male Munich-Wistar rats, we assessed the functional role of renal β-adrenoceptors in mediating neural control of glomerular filtration and proximal tubular reabsorption. The determinants of nephron filtration and rate of proximal tubular reabsorption were measured in two groups of animals before and after acute surgical renal denervation (DNX). Group A animals (n = 6) were pretreated with the β-adrenoceptor antagonist proprmolol (25 mg/kg body weight per day for 4–6 days). Group B animals (n = 7) served as non–β-blocked controls. Acute renal DNX resulted in no significant change in nephron filtration rate or any of its determinants in either group. Acute DNX caused similar decrements in the rate of fluid reahsorption from the proximal convoluted tubule of β-blocked and control rats. Loop of Henle fluid reahsorption did not appear to he affected by DNX in either group. Because the effect of denervation on proximal tubular reabsorption was not conditioned by prior β-blockade, the β-adrenoceptors present within the proximal convoluted tubule do not appear to he the primary mediators of the adrenergic influence on fluid transport in that segment of the nephron.
Details
- Language :
- English
- ISSN :
- 01602446 and 15334023
- Volume :
- 17
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Cardiovascular Pharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs49053995