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The Nucleic Acid Scavenger Polyamidoamine Third-Generation Dendrimer Inhibits Fibroblast Activation and Granulation Tissue Contraction
- Source :
- Plastic and Reconstructive Surgery; September 2014, Vol. 134 Issue: 3 p420e-433e, 14p
- Publication Year :
- 2014
-
Abstract
- Pathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic scarring. The authors hypothesize that nucleic acids increase fibroblast activation and cause granulation tissue contraction and that sequestration of nucleic acids by application of a nucleic acid scavenger dendrimer, polyamidoamine third-generation dendrimer, will decrease pathologic scarring.
Details
- Language :
- English
- ISSN :
- 00321052 and 15294242
- Volume :
- 134
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Plastic and Reconstructive Surgery
- Publication Type :
- Periodical
- Accession number :
- ejs49194349
- Full Text :
- https://doi.org/10.1097/PRS.0000000000000471