Back to Search
Start Over
IL-4 Deficiency Prevents Eosinophilic Rejection and Uncovers a Role for Neutrophils in the Rejection of MHC Class II Disparate Skin Grafts
- Source :
- Transplantation; November 2005, Vol. 80 Issue: 10 p1485-1492, 8p
- Publication Year :
- 2005
-
Abstract
- Acute rejection of MHC class II-disparate bm12 skin grafts by C57BL/6 recipient mice is characterized by massive graft infiltration by eosinophils, together with increased intragraft amounts of IL-4 and IL-5 mRNA. IL-5 blockade prevents the intragraft eosinophil infiltration and prolongs the survival of skin allografts. As the differentiation of T cell precursors into Th2 cells is largely driven by IL-4, we investigated the role of IL-4 in MHC class II-disparate allograft rejection.
Details
- Language :
- English
- ISSN :
- 00411337 and 15346080
- Volume :
- 80
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs49274391
- Full Text :
- https://doi.org/10.1097/01.tp.0000176486.01697.3f