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One-pot Synthesis of Hollongdione from Dipterocarpol
- Source :
- Natural Product Communications; October 2014, Vol. 9 Issue: 10
- Publication Year :
- 2014
-
Abstract
- A one-pot synthesis of a hybrid triterpenoid-steroid molecule, hollongdione (22,23,24,25,26,27-hexanordammar-3,20-dion), was achieved in a yield of 89%, based on the selective dehydration of dipterocarpol following ozonolysis. The structure of hollongdione was confirmed by X-ray analysis for the first time. Dammar-20(22),24(25)-dien inhibited the growth of Mycobacterium tuberculosis(strain H37Rv) in vitrowith a MIC of 50 μg/mL.
Details
- Language :
- English
- ISSN :
- 1934578X and 15559475
- Volume :
- 9
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Natural Product Communications
- Publication Type :
- Periodical
- Accession number :
- ejs49640821
- Full Text :
- https://doi.org/10.1177/1934578X1400901005