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Anti-adipogenic Activity of Cordyceps militarisin 3T3-L1 Cells

Anti-adipogenic Activity of Cordyceps militarisin 3T3-L1 Cells

Authors :
Liu, Qing
Hong, In Pyo
Ahn, Mi-Jeong
Yoo, Hwan-Soo
Han, Sang-Bae
Hwang, Bang Yeon
Lee, Mi Kyeong
Source :
Natural Product Communications; December 2011, Vol. 6 Issue: 12
Publication Year :
2011

Abstract

Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment of obesity. In our present study, Cordyceps militarisshowed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of cordycepin (1), guanosine (2) and tryptophan (3) as active compounds. All the three compounds were more effective in the prevention of early stage of adipogenesis than in lipolysis. In addition, combinational treatment of three compounds significantly increased anti-adipogenic activity.

Details

Language :
English
ISSN :
1934578X and 15559475
Volume :
6
Issue :
12
Database :
Supplemental Index
Journal :
Natural Product Communications
Publication Type :
Periodical
Accession number :
ejs49647731
Full Text :
https://doi.org/10.1177/1934578X1100601213