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Anti-adipogenic Activity of Cordyceps militarisin 3T3-L1 Cells
Anti-adipogenic Activity of Cordyceps militarisin 3T3-L1 Cells
- Source :
- Natural Product Communications; December 2011, Vol. 6 Issue: 12
- Publication Year :
- 2011
-
Abstract
- Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment of obesity. In our present study, Cordyceps militarisshowed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of cordycepin (1), guanosine (2) and tryptophan (3) as active compounds. All the three compounds were more effective in the prevention of early stage of adipogenesis than in lipolysis. In addition, combinational treatment of three compounds significantly increased anti-adipogenic activity.
Details
- Language :
- English
- ISSN :
- 1934578X and 15559475
- Volume :
- 6
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Natural Product Communications
- Publication Type :
- Periodical
- Accession number :
- ejs49647731
- Full Text :
- https://doi.org/10.1177/1934578X1100601213