Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candidaand AspergillusSpecies for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods

Although the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candidaor Aspergillusspecies. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrataspecies complex, 157 C.guilliermondii(Meyerozyma guilliermondii), 676 C. krusei(Pichia kudriavzevii), 298 C.lusitaniae(Clavispora lusitaniae), 911 C.parapsilosissensu stricto, 3,691 C.parapsilosisspecies complex, 36 C.metapsilosis, 110 C.orthopsilosis, 1,854 C.tropicalis, 244 Saccharomyces cerevisiae, 1,409 Aspergillus fumigatus, 389 A.flavus, 130 A.nidulans, 233 A.niger, and 302 A.terreuscomplex isolates.