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Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial

Authors :
Merle, Philippe
Blanc, Jean-Frederic
Phelip, Jean-Marc
Pelletier, Gilles
Bronowicki, Jean-Pierre
Touchefeu, Yann
Pageaux, Georges
Gerolami, René
Habersetzer, François
Nguyen-Khac, Eric
Casadei-Gardini, Andrea
Borbath, Ivan
Tran, Albert
Wege, Henning
Saad, Amr Shafik
Colombo, Massimo
Abergel, Armand
Richou, Carine
Waked, Imam
Yee, Nelson S
Molé, Audrey
Attali, Pierre
Le Boulicaut, Julie
Vasseur, Bérangère
Moussata, Driffa
Grangé, Jean-Didier
Ratziu, Vlad
Khemissa-Akouz, Faiza
Regnault, Hélène
Dauvois, Barbara
Zarski, Jean-Pierre
Ollivier-Hourmand, Isabelle
Manfredi, Sylvain
Debette-Gratien, Marilyne
Gangloff, Alice
Fontanges, Thierry
Baron, Aurore
Bouattour, Mohamed
Vincent, Julie
Sieghart, Wolfgang
Maieron, Andreas
Peeters, Marc
Delwaide, Jean
Lasser, Luc
Berg, Thomas
Schultheiß, Michael
Zipprich, Alexander
Trojan, Joerg
Ehmer, Ursula
Luppi, Gabriele
Luca, Giovanni
Tamberi, Stefano
Amoroso, Domenico
Alabiso, Oscar
Buonadonna, Angela
Toniutto, Pierluigi
Tamburini, Emiliano
Cubillo, Antonio
Muñoz, Andrés
Guillén, Carmen
Sánchez, Gloria
Manzano, Hermini
Navarro, Victor
Ales, Inmaculada
Massuti, Bartomeu
Dank, Magdolna
Bodoky, György
Kahan, Zsuzsanna
Horváth, Zsolt
Gabrail, Nashat
Ozer, Howard
Galanopoulos, Christos
Hauke, Ralph
Raj, Moses
Harputluoglu, Hakan
Sevinc, Alper
Goker, Erdem
Coker, Ahmet
Yalcin, Suayib
Ali, Muhammet
Ata, Ozlem
Tugba, Ilkay
El Kassas, Mohammed
Abdel, Amr
Wakid, Imam
Shamaa, Sameh
El Lahlouby, Nasr
Kohail, Hanaa
Makarem, Jawad
Chehade, Issam
Farhat, Fadi
López, Carlos
Marín, Miguel
Source :
The Lancet Gastroenterology & Hepatology; June 2019, Vol. 4 Issue: 6 p454-465, 12p
Publication Year :
2019

Abstract

Cytotoxic chemotherapy is generally ineffective in patients with hepatocellular carcinoma. We assessed the intravenous perfusion of doxorubicin-loaded nanoparticles in patients with hepatocellular carcinoma in whom previous sorafenib therapy had failed.

Details

Language :
English
ISSN :
24681253
Volume :
4
Issue :
6
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs49978794
Full Text :
https://doi.org/10.1016/S2468-1253(19)30040-8