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Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis

Authors :
Stevens, Whitney W.
Peters, Anju T.
Tan, Bruce K.
Klingler, Aiko I.
Poposki, Julie A.
Hulse, Kathryn E.
Grammer, Leslie C.
Welch, Kevin C.
Smith, Stephanie S.
Conley, David B.
Kern, Robert C.
Schleimer, Robert P.
Kato, Atsushi
Source :
The Journal of Allergy and Clinical Immunology: In Practice; November-December 2019, Vol. 7 Issue: 8 p2812-2820.e3
Publication Year :
2019

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by mucosal inflammation in the nose and paranasal sinuses. Inflammation in CRS is also heterogeneous and is mainly characterized by type 2 (T2) inflammation, but subsets of patients show type 1 (T1) and type 3 (T3) inflammation. Whether inflammatory endotypes are associated with clinical phenotypes has yet to be explored in detail.

Details

Language :
English
ISSN :
22132198
Volume :
7
Issue :
8
Database :
Supplemental Index
Journal :
The Journal of Allergy and Clinical Immunology: In Practice
Publication Type :
Periodical
Accession number :
ejs50161282
Full Text :
https://doi.org/10.1016/j.jaip.2019.05.009