New Unsaturated Lactones and a Meroterpenoid from Ganoderma lucidum

From the dried fruiting bodies of Ganoderma lucidum, 2 new unsaturated lactones, dayaolingzhilactones A and B (1and 2), and 1 new meroterpenoid, dayaolingzhiol H (3), together with 10 known compounds (4-13), were isolated. Their chemical structures were identified by using spectroscopic data and calculated specific rotation. The inhibitory activities of compounds 1and 2toward acetylcholinesterase (AchE) were assessed in vitro with tacrine as the positive control. Both of them exhibited moderate AchE inhibitory activities at the concentration of 50 μM.