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Direct C3 Alkoxylation of Quinoxalin-2(1H)-ones with Alcohols via Cross-Dehydrogenative Coupling under Catalyst-Free Conditions
- Source :
- The Journal of Organic Chemistry; September 2019, Vol. 84 Issue: 18 p11417-11424, 8p
- Publication Year :
- 2019
-
Abstract
- A facile and effective alkoxylation protocol of quinoxalin-2(1H)-ones with primary or secondary alcohols via cross-dehydrogenative coupling under catalyst-free conditions has been disclosed. This method provides a powerful and convenient access to 3-alkoxylquinoxalin-2(1H)-ones in good to excellent yields by utilizing PhI(OTFA)2as an oxidant and allows to easily obtain potential drug molecules containing 3-alkoxylquinoxalin-2(1H)-one skeletons.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 84
- Issue :
- 18
- Database :
- Supplemental Index
- Journal :
- The Journal of Organic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs50796535
- Full Text :
- https://doi.org/10.1021/acs.joc.9b01181