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Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy
- Source :
- Pharmacological Reports; October 2019, Vol. 71 Issue: 5 p958-967, 10p
- Publication Year :
- 2019
-
Abstract
- •NEPi and ACE2 activator combination increased cGMP, inhibited fibrosis and apoptosis in diabetic heart.•Ability to reverse H3K4Me2 and its methyl transferases expressions may add to its cardioprotective potential.•NEPi and ACE2 activator combination can be a novel therapeutic strategy against diabetic cardiomyopathy.
Details
- Language :
- English
- ISSN :
- 17341140
- Volume :
- 71
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Pharmacological Reports
- Publication Type :
- Periodical
- Accession number :
- ejs50855580
- Full Text :
- https://doi.org/10.1016/j.pharep.2019.05.008