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Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

Authors :
Goedeke, Leigh
Peng, Liang
Montalvo-Romeral, Valle
Butrico, Gina M.
Dufour, Sylvie
Zhang, Xian-Man
Perry, Rachel J.
Cline, Gary W.
Kievit, Paul
Chng, Keefe
Petersen, Kitt Falk
Shulman, Gerald I.
Source :
Science Translational Medicine; October 2019, Vol. 11 Issue: 512
Publication Year :
2019

Abstract

Liver-targeted mitochondrial uncoupling improves dyslipidemia and reduces hepatic triglyceride content in obese nonhuman primates.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
11
Issue :
512
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs51112365
Full Text :
https://doi.org/10.1126/scitranslmed.aay0284