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Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
Authors :
McClung, Michael R O'Donoghue, Michelle L Papapoulos, Socrates E Bone, Henry Langdahl, Bente Saag, Kenneth G Reid, Ian R Kiel, Douglas P Cavallari, Ilaria Bonaca, Marc P Wiviott, Stephen D de Villiers, Tobias Ling, Xu Lippuner, Kurt Nakamura, Toshitaka Reginster, Jean-Yves Rodriguez-Portales, Jose Adolfo Roux, Christian Zanchetta, José Zerbini, Cristiano A F Park, Jeong-Gun Im, KyungAh Cange, Abby Grip, Laura T Heyden, Norman DaSilva, Carolyn Cohn, Dosinda Massaad, Rachid Scott, Boyd B Verbruggen, Nadia Gurner, Deborah Miller, Deborah L Blair, Micki L Polis, Adam B Stoch, S Aubrey Santora, Arthur Lombardi, Antonio Leung, Albert T Kaufman, Keith D Sabatine, Marc S Mautalén, Carlos Alfredo Man, Zulema Zanchetta, Jose Ruben Magaril, Clelia Haydee Sambrook, Philip Reginster, Jean-Yves Geusens, Piet Goemaere, Stefan Albergaria, Ben Hur Zerbini, Cristiano Augusto de Freitas Castro, Marise Lazaretti Gregorio, Luiz Henrique Stoilov, Rumen Borissova, Anna-Maria I Hristozov, Kiril Hristov Temelkova, Nataliya L Daskalova, Ivona Kirilova Kuzmanova, Stefka Ivanova Yaneva-Bichovska, Daniela Batalov, Anastas Zgurov Riedemann, Pablo Rodriguez Portales, José Adolfo Tang, Hai Zhu, hanmin Zhang, Zhenlin Chao, Aijun Hu, Yali Liu, Zhiming Lu, Juming Qiu, Mingcai Gao, Xin Zhang, Shaofen Xu, Ling Xia, Weibo Liao, Eryuan Yang, Wenying Wu, Wen Dai, Kerong Hu, Renming Tang, Hai Jaller, Juan Jose Cabal, Francisco Molina, José Fernando Cure Cure, Carlos A Yupanqui-Lozno, Hernan Chalem, Philippe Londono, John Abello, Mauricio Tobias, Edgardo D Otero, William Nikolic, Tatjana Miskic, Blazenka Stepan, Jan Vyskocil, Vaclav Novosad, Libor Slesinger, Jan Novosad, Pavel Vlckova, Erika Bortlik, Ladislav Dokoupilova, Eva Hala, Tomas Jensen, Jens-Erik Beck Brixen, Kim Torsten Langdahl, Bente Lomholt Schwarz, Peter Eskildsen, Peter Claes Eiken, Pia Agnete Hermann, Anne Pernille Gram, Jeppe Schou, Maiken Brix Alexandersen, Peter Nedergaard, Bettina Mejía, Dolores Magdalena Estrella De Henriquez, Lourdes Páez, Norka Velazco, Casimiro Valter, Ivo Vahula, Kadri-Liina Kull, Ingrid Maasalu, Katre Chapurlat, Roland Fardellone, Patrice Benhamou, Claude Laurent Roux, Christian Weryha, Georges Herkt, Volkmar Martz, Rene Nischik, Ruth Spieler, Wolfgang Contzen, Christel Felsenberg, Dieter Frieling, Isolde Frahm, Eike Briones, Henry Sandoval, Boris Barrios, Patricia García, Abraham Avendaño, Carlos González, Magdalena Guerra, Jeremías Tuna, Maria Díaz, Olga Marina Samayoa, Eduardo López, Edgar Barrera, José Raúl Palencia, Mainor Cifuentes, Mayra Alvarado, Georgina López, Miriam Chavez, Nilmo Haase, Franklin Rivera, Ruddy González, Claudio Tan, Kathryn Leung, Ping Chung Mandalam, Sheshadri Pitale, Shailesh Umakant Bantwal, Ganapathi Ammini, Ariachery Chinamma Shaikh, Shehla Sajid Akhta Kanakatte Mylariah, Prasanna Kumar Dharmalingam, Mala Mukhopadhyay, Satinath Jain, Arpit Singh, Parminder Shetty, Naresh Sathyanarayana, Srikanta Shamanna Shah, Nalini Chadha, Manoj Dharam Bhandankar, Rajendra Velayutham, Kumaravel Marwah, Sudha John, Mathew Sahay, Rakesh Kumar Adami, Silvano Nuti, Ranuccio Bianchi, Gerolamo Brandi, Maria Luisa Minisola, Salvatore Fiore, Carmelo Erio Rubinacci, Alessandro Miyajima, Hisayuki Yamane, Hiroo Nakatani, Yuji Okamoto, Sumiaki Kuroda, Koji Fujimori, Motoaki Itabashi, Akira Katayama, Kuniaki Nakajo, Satoru Somekawa, Yoshiaki Ohsawa, Yoshimitsu Tajima, Wataru Mizuno, Katsunori Mori, Shigeru Kanabuchi, Takato Hashizume, Hiroyuki Oka, Nobuyuki Hamada, Kazutoshi Yamaguchi, Motoi Hirahara, Fumiki Atobe, Masaaki Ohtake, Yoshiharu Ichikawa, Shuichi Onishi, Tomoyuki Matsumoto, Kou Nakamura, Tetsuro Shirasawa, Eishi Katayama, Ko Takahashi, Mitsugu Oguma, Tadanori Matsui, Hideo Katoh, Yoshiharu Shigenobu, Keiichi Onishi, Tsutomu Shibukawa, Masato Ikeda, Satoshi Osaka, Kazuhiro Kanda, Ryosuke Inobe, Yoshito Shigenobu, Masaharu Hasegawa, Morimasa Yamaji, Tetsuo Miyazaki, Yu Ito, Takayasu Nakamura, Eisuke Nagai, Shinji Lim, Sung-Kil Chung, Yoon-Sok Shin, Chan-Soo Min, Yong-Ki Kim, Ghi Su Yoon, Hyun Koo Kang, Moo-Il Yang, Kyu-Hyun Park, Hyoung Moo Kim, In Joo Chung, Dong Jin Chung, Ho Yeon Jaundzeikare, Sandra Andersone, Dace Medne, Agita Yaghi, Yasser Alekna, Vidmantas Kasiulevicius, Vytautas Purtokaite - Labutiniene, Irina Krasauskiene, Aurelija Varanaviciene, Jurate Basijokiene, Vida Abraitiene, Agne Radzeviciene, Lina Walliser, Jesus García Hernández, Pedro Alberto Araujo, Maria Frida Avila Armengol, Hilario Ernesto De la Peña, Pilar Tamayo, Juan Zazueta, Beatriz Cons, Fidencio Gilchrist, Nigel Leslie Reid, Ian Reginald Leikis, Robert Jones, Peter Singh, Joe Gragrath Pradeep Halse, Johan Inge Syversen, Unni Høivik, Hans Olav Øfjord, Erik Snorre Gulseth, Hans Christian Elle, Sigbjørn Norheim, Paal Dag Calvo Quiroz, Armando A. Cesar Augusto, Pastor A. León Portocarrero, Manuel Gustavo Vidal Neira, Luis Fernando Chavez, Jose Garro Barrera, Boris Kuroiwa Sampei, Rita Luis Fernando, Bellatín V. Oquelis Cabredo, Rogger Castillo, Sonia Morales, Agustin Miguel G Tan, Perry Pua Leagogo, Liberato Antonio C Wang, Edward HM Li-Yu, Julie T Sawicki, Andrzej Z Stasiuk, Barbara Kania, Grzegorz Lorenc, Roman Sidorowicz-Bialynicka, Anna Szczepanski, Leszek Franek, Edward Filip, Rafal Sekula, Jan Blicharski, Tomasz Leszczynski, Piotr Sewerynek, Ewa Miazgowski, Tomasz Milewicz, Andrzej Dabrowska, Magda Romaszko, Jerzy Pluskiewicz, Wojciech Wojnowski, Lukasz Codreanu, Catalin Bolosiu, Horatiu Ionescu, Ruxandra Zosin, Ioana Macovei, Liviu Bojinca, Mihai Radulescu, Florin Pop, Simona Sarbu, Adrian Benevolenskaya, Lidia I Nasonov, Evgeny L Rozhinskaya, Lyudmila Ya Oganov, Raphael G Rodionova, Svetlana S Shlyakhto, Eugeny Vladimirovich Trofimov, Vasiliy Zotkin, Eugeny G Zazerskaya, Irina E Grineva, Elena N Ershova, Olga Lesnyak, Olga Ostroumova, Olga D Malichenko, Svetlana B Pikhlak, Eduard G Pilyaev, Valery G Raskina, Tatiana Zonova, Elena V Shirinsky, Valery S Dimic, Aleksandar N Cobeljic, Goran Vujovic, Svetlana Ellis, Graham Charlston Lipschitz, Stanley De Villiers, Tobias Johannes De Weerd, Albert Jan Vally, Tasneem Trinder, Yvonne Coetsee, Jacobus Ludewikus Davis, Charles Pierre Nayiager, Savithree Hough, Frans Stephanus Oelofse, Louis F van der Walt, Eugene Lombaard, Johannes Jurgens Blignaut, Suzanne Govind, Uttam Fouche, Leon Frederik Kruger, Dawid Stephanus Dalmeyer, Johannes Paul Ferreira, Mada M Escudero-Contreras, Alejandro Muñoz Torres, Manuel Hawkins Carranza, Federico Perez Castrillon, Jose Luis García Meijide, Juan Antonio Jodar Gimeno, Esteban Palacios Gil-Antuñana, Santiago de Teresa Parreno, Luis Martín Mola, Emilio Alvarez Sanchez, Carmen Lippuner, Kurt Tsai, Keh-Sung Tu, Shih-Te Chen, Jung-Fu Lee, Oscar Kuang-Sheng Hsu, Wen-Wei Grygorieva, Natalia Viktorivna Povoroznyuk, Vladyslav Volodymyrovych Korzh, Mykola Oleksiiovych Loskutov, Oleksandr Levgeniiovych Chukov, Andriy Borysovych Sarmiento, Rex Thomas, Hawys Donnachie, Hugh Pavel-Knox, Irina Shaw, Hilary Hassanin, Hana Abdulhakim, Essam Eldin Ahmed Savani, Naren Bachmann, Gloria A Barrett-Connor, Elizabeth Binkley, Neil C Bone, Henry G Brandon, Donald M Checketts, Darin David Fraser, Neil J Watts, Nelson B Geller, Steven A Gimbel, Joseph S Greenwald, Maria White Holt, Peter A Johnston, Cyrus Conrad Fang, Chien Kiel, Douglas P Klashman, David J Lewiecki, E. Michael Lowenstein, Mitchell B McClung, Michael Roy Nattrass, Susan M Odio, Alberto Levengood, Julie Romaguera, Josefina Saag, Kenneth G Sebai, Mohamed Bassam Snyder, Brian Kutner, Mark Eliot Streja, Dan Schwartz, Elliott P Christiansen, Mark G
Source :
The Lancet Diabetes & Endocrinology; December 2019, Vol. 7 Issue: 12 p899-911, 13p
Publication Year :
2019
Abstract
Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal women with low bone mass. We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis.
Details
Language :
English
ISSN :
22138587 and 22138595
Volume :
7
Issue :
12
Database :
Supplemental Index
Journal :
The Lancet Diabetes & Endocrinology
Publication Type :
Periodical
Accession number :
ejs51580816
Full Text :
https://doi.org/10.1016/S2213-8587(19)30346-8