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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
Authors :
Younossi, Zobair M Ratziu, Vlad Loomba, Rohit Rinella, Mary Anstee, Quentin M Goodman, Zachary Bedossa, Pierre Geier, Andreas Beckebaum, Susanne Newsome, Philip N Sheridan, David Sheikh, Muhammad Y Trotter, James Knapple, Whitfield Lawitz, Eric Abdelmalek, Manal F Kowdley, Kris V Montano-Loza, Aldo J Boursier, Jerome Mathurin, Philippe Bugianesi, Elisabetta Mazzella, Giuseppe Olveira, Antonio Cortez-Pinto, Helena Graupera, Isabel Orr, David Gluud, Lise Lotte Dufour, Jean-Francois Shapiro, David Campagna, Jason Zaru, Luna MacConell, Leigh Shringarpure, Reshma Harrison, Stephen Sanyal, Arun J Abdelmalek, Manal Abrams, Gary Aguilar, Humberto Ahmed, Aijaz Aigner, Elmar Aithal, Guruprasad Ala, Aftab Alazawi, William Albillos, Agustin Allison, Michael Al-Shamma, Sfa Andrade, Raul Andreone, Pietro Angelico, Mario Ankoma-Sey, Victor Anstee, Quentin Anty, Rodolphe Araya, Victor Arenas Ruiz, Juan Ignacio Arkkila, Perttu Arora, Marty Asselah, Tarik Au, Jennifer Ayonrinde, Oyekoya Bailey, Robert James Balakrishnan, Maya Bambha, Kiran Bansal, Meena Barritt, Sidney Bate, John Beato, Jorge Beckebaum, Susanne Behari, Jaideep Bellot, Pablo Ben Ari, Ziv Bennett, Michael Berenguer, Marina Beretta-Piccoli, Benedetta Terziroli Berg, Thomas Bonacini, Maurizio Bonet, Lucia Borg, Brian Bourliere, Marc Boursier, Jerome Bowman, William Bradley, David Brankovic, Marija Braun, Marius Bronowicki, Jean-Pierre Bruno, Savino Bugianesi, Elisabetta Cai, Cindy Calderon, Amy Calleja Panero, José Luis Carey, Elizabeth Carmiel, Michal Carrión, Jose Antonio Cave, Matthew Chagas, Cristina Chami, Tawfik Chang, Alan Coates, Allan Cobbold, Jeremy Costentin, Charlote Corey, Kathleen Corless, Lynsey Cortez-Pinto, Helena Crespo, Javier Cruz Pereira, Oscar de Ledinghen, Victor deLemos, Andrew Diago, Moises Dong, Mamie Dufour, Jean-François Dugalic, Predrag Dunn, Winston Elkhashab, Magby Epstein, Michael Escudero-Garcia, Maria Desamparados Etzion, Ohad Evans, Larry Falcone, Robert Fernandez, Conrado Ferreira, Jose Fink, Scott Finnegan, Kevin Firpi-Morell, Roberto Floreani, Annarosa Fontanges, Thierry Ford, Ryan Forrest, Ewan Fowell, Andrew Fracanzani, Anna Ludovica Francque, Sven Freilich, Bradley Frias, Juan Fuchs, Michael Fuentes, Javier Galambos, Michael Gallegos, Juan Geerts, Anja Geier, Andreas George, Jacob Ghali, Maged Ghalib, Reem Gholam, Pierre Gines, Pere Gitlin, Norman Gluud, Lise Lotte Goeser, Tobias Goff, John Gordon, Stuart Gordon, Frederic Goria, Odile Greer, Shaun Grigorian, Alla Gronbaek, Henning Guillaume, Maeva Gunaratnam, Naresh Halegoua-De Marzio, Dina Hameed, Bilal Hametner, Stephanie Hamilton, James Harrison, Stephen Hartleb, Marek Hassanein, Tarek Häussinger, Dieter Hellstern, Paul Herring, Robert Heurich, Eva Hezode, Christophe Hinrichsen, Holger Holland Fischer, Peter Horsmans, Yves Huang, Jonathan Hussaini, Hyder Jakiche, Antoine Jeffers, Lennox Jones, Blake Jorge, Rosa Jorquera, Francisco Joshi, Shoba Kahraman, Alisan Kaita, Kelly Karyotakis, Nicholas Kayali, Zeid Kechagias, Stergios Kepczyk, Thomas Khalili, Mandana Khallafi, Hicham Kluwe, Johannes Knapple, Whitfield Kohli, Anita Korenblat, Kevin Kowdley, Kris Krag, Aleksander Krause, Richard Kremer, Andreas Krok, Karen Krstic, Miodrag Kugelmas, Marcelo Kumar, Sonal Kuwada, Scott Labarriere, Damien Lai, Michelle Laleman, Wim Lampertico, Pietro Lawitz, Eric Lee, Alice Leroy, Vincent Lidofsky, Steven Lim, Tina Huey Lim, Joseph Lipkis, Donald Little, Ester Lonardo, Amadeo Long, Michelle Loomba, Rohit Luketic, Velimir Anthony Christopher Lurie, Yoav Macedo, Guilherme Magalhaes, Joana Makara, Mihály Maliakkal, Benedict Manns, Michael Manousou, Pinelopi Mantry, Parvez Marchesini, Giulio Marinho, Carla Marotta, Paul Marschall, Hanns-Ulrich Martinez, Linda Mathurin, Philippe Mayo, Marlyn Mazzella, Giuseppe McCullen, Mark McLaughlin, William Merle, Uta Merriman, Raphael Modi, Apurva Molina, Esther Montano-Loza, Aldo Monteverde, Carlos Morales Cardona, Amilcar Moreea, Sulleman Moreno, Christophe Morisco, Filomena Mubarak, Abdullah Muellhaupt, Beat Mukherjee, Sandeep Müller, Tobias Nagorni, Aleksandar Naik, Jahnavi Neff, Guy Nevah, Moises Newsome, Philip Nguyen-Khac, Eric Noureddin, Mazen Oben, Jude Olveira, Antonio Orlent, Hans Orr, David Orr, James Ortiz-Lasanta, Grisell Ozenne, Violaine Pandya, Prashant Paredes, Angelo Park, James Patel, Joykumar Patel, Keyur Paul, Sonali Patton, Heather Peck-Radosavljevic, Markus Petta, Salvatore Pianko, Stephen Piekarska, Anna Pimstone, Neville Pisegna, Joseph Pockros, Paul Pol, Stanislas Porayko, Michael Poulos, John Pound, David Pouzar, Joe Presa Ramos, Jose Pyrsopoulos, Nikolaos Rafiq, Nila Muller, Kate Ramji, Alnoor Ratziu, Vlad Ravinuthala, Ravi Reddy, Chakradhar Reddy K G, Gautham Reddy K R, K. Rajender Regenstein, Frederic Reindollar, Robert Reynolds, Justin Riera, Andres Rinella, Mary Rivera Acosta, Jose Robaeys, Geert Roberts, Stuart Rodriguez-Perez, Federico Romero, Sandor Romero-Gomez, Manuel Rubin, Raymond Rumi, Mariagrazia Rushbrook, Simon Rust, Christian Ryan, Michael Safadi, Rifaat Said, Adnan Salminen, Kimmo Samuel, Didier Santoro, John Sanyal, Arun Sarkar, Souvik Schaeffer, Cynthia Schattenberg, Jörn Schiefke, Ingolf Schiff, Eugene Schmidt, Wolfgang Schneider, Jeffrey Schouten, Jeoffrey Schultz, Michael Sebastiani, Giada Semela, David Sepe, Thomas Sheikh, Aasim Sheikh, Muhammad Sheridan, David Sherman, Kenneth Shibolet, Oren Shiffman, Mitchell Siddique, Asma Sieberhagen, Cyril Sigal, Samuel Sikorska, Katarzyna Simon, Krzysztof Sinclair, Marie Skoien, Richard Solis, Joel Sood, Siddharth Souder, Bob Spivey, James Stal, Per Stinton, Laura Strasser, Simone Svorcan, Petar Szabo, Gyongzi Talal, Andrew Tam, Edward Tetri, Brent Thuluvath, Paul Tobias, Hillel Tomasiewicz, Krzysztof Torres, Dawn Tran, Albert Trauner, Michael Trautwein, Christian Trotter, James Tsochatzis, Emanuel Unitt, Esther Vargas, Victor Varkonyi, Istvan Veitsman, Ella Vespasiani Gentilucci, Umberto Victor, David Vierling, John Vincent, Catherine Vincze, Aron von der Ohe, Manfred Von Roenn, Natasha Vuppalanchi, Raj Waters, Michael Watt, Kymberly Wattacheril, Julia Weltman, Martin Wieland, Amanda Wiener, Gregory Williams A, Alonzo Williams J, Jeffrey Wilson, Jason Yataco, Maria Yoshida, Eric Younes, Ziad Yuan, Liyun Zivony, Adam Zogg, Donald Zoller, Heinz Zoulim, Fabien Zuckerman, Eli Zuin, Massimo
Source :
The Lancet; December 2019, Vol. 394 Issue: 10215 p2184-2196, 13p
Publication Year :
2019
Abstract
Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
394
Issue :
10215
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs51716304
Full Text :
https://doi.org/10.1016/S0140-6736(19)33041-7