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Genetic Manipulation of an Aminotransferase Family Gene dtlAActivates Youssoufenes in Marine-Derived Streptomyces youssoufiensis

Authors :
Li, Huayue
Liu, Jing
Deng, Zirong
Li, Tong
Liu, Zengzhi
Che, Qian
Li, Wenli
Source :
Organic Letters; January 2020, Vol. 22 Issue: 2 p729-733, 5p
Publication Year :
2020

Abstract

Disruption of an aminotransferase family gene dtlAactivated the production of a novel dimeric benzoic polyene acids (BPAs), named youssoufene A1 (1), along with four new (2–5, youssoufenes B1–B4) and a known (6) monomeric BPA in the marine-derived Streptomyces youssoufiensisOUC6819. The structures of 1–5were elucidated by extensive spectroscopic and computational approaches. Youssoufene A1 (1) exhibited notably increased growth inhibition (MIC = 12.5 μg/mL) against multidrug resistant Enterococcus faecaliscompared to monomeric structures (2–6).

Details

Language :
English
ISSN :
15237060 and 15237052
Volume :
22
Issue :
2
Database :
Supplemental Index
Journal :
Organic Letters
Publication Type :
Periodical
Accession number :
ejs51994847
Full Text :
https://doi.org/10.1021/acs.orglett.9b04559