Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia

•Dynorphin and enkephalin are opioid peptides involved in spinal nociceptive modulation.•Peptide and mRNA were measured by Radioimmunoassay and RNA-Seq after peripheral inflammation.•Marked upregulation of prodynorphin mRNA and dynorphin A 1-8 occurred.•In situ hybridization localized the neurons mainly to medial dorsal horn.•RNA-Seq data mining of dynorphin in dorsal root ganglion revealed a role in nerve injury.